Results
| PMID | 26350109 |
| Gene Name | GSTT1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 218 |
| Population details | 218 (121 confirmed endometriosis, 97 women without evidence of endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
J Assist Reprod Genet. 2015 Oct;32(10):1531-5. doi: 10.1007/s10815-015-0554-7. Kubiszeski, Eloisa Helena| de Medeiros, Sebastiao Freitas| da Silva Seidel, Joziane Agnoria| Barbosa, Jacklyne Silva| Galera, Marcial Francis| Galera, Bianca Borsatto Federal University of Mato Grosso-UFMT, Cuiaba, MT, Brazil. eloisahelenak@yahoo.com.br.| , Av. Fernando Correa da Costa, n degrees 2367-Bairro Boa Esperanca, Cuiaba, MT, ZIPMAIL: 78060-900, Brazil. eloisahelenak@yahoo.com.br.| Federal University of M PURPOSE: The glutathione family (GST) genes appear to play a role in the genesis of endometriosis. This case-control study aimed to compare the frequencies of GSTM1 and GSTT1 polymorphisms in women with endometriosis and women without endometriosis. METHODS: Polymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97). RESULT(S): No differences in the frequencies of GSTM1 polymorphism (null genotype) were observed between the cases and controls: odds ratio (OR) = 1.13; 95 % CI 0.656-1.93 (p = 0.659). The GSTT1 polymorphism (null genotype) was more prevalent in the endometriosis group than in the control group (OR = 0.53; 95 % CI 0.94-0.29 (p = 0.039). No relationship between menstrual cycle interval and GSTM1 null genotype frequency was observed in either cases or controls (p = 0.370 and p = 0.664, respectively). In addition, no relationship between menstrual cycle interval and GSTT1 null genotype was observed in cases (p = 0.797) or controls (p = 0.052). CONCLUSIONS: GSTM1 null genotype frequency was similar between cases and controls. The GSTT1 null genotype was more frequent in the control group. Mesh Terms: Adult| Brazil| Case-Control Studies| Endometriosis/*genetics| Female| Gene Frequency| Genetic Predisposition to Disease| Glutathione Transferase/*genetics| Humans| Menstrual Cycle/genetics| *Polymorphism, Genetic|DA 2016/08/02 06:00 |
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